The in-vitro effects of medroxyprogesterone acetate on acidic pH induced apoptosis of periferal blood mononuclear cells

Medroxyprogesterone acetate (MPA) which has a steroid structure, is widely used in oncology practice in the treatment of the cachexia of cancer and to reduce hematologic toxicity in patients receiving chemotherapy. However, the mechanisms of MPA on these effects are unclear. In this study, we invest...

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Bibliographic Details
Published inJournal of experimental & clinical cancer research Vol. 23; no. 1; p. 93
Main Authors Ozdemir, F, Ovali, E, Aydin, F, Kavgaci, H, Büyükcelik, A, Ucar, F, Sönmez, M
Format Journal Article
LanguageEnglish
Published England 01.03.2004
Subjects
Adult
Antineoplastic Agents, Hormonal - pharmacology
Apoptosis
Cell Cycle
Cell Division
Cell Survival
Female
Flow Cytometry
Humans
Hydrogen-Ion Concentration
Leukocytes, Mononuclear - drug effects
Male
Medroxyprogesterone Acetate - pharmacology
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Summary:Medroxyprogesterone acetate (MPA) which has a steroid structure, is widely used in oncology practice in the treatment of the cachexia of cancer and to reduce hematologic toxicity in patients receiving chemotherapy. However, the mechanisms of MPA on these effects are unclear. In this study, we investigated the effects of two different doses of MPA (10(-5) and 10(-6) M/L) on acidic pH induced apoptosis of periferal blood mononuclear cells (PBMC) derived from 10 healthy volunteers. Compared with the control group, we found that MPA at the dose of 10(-5) M/L had a negative effect on apoptosis (32.88 +/- 4.61 and 20.7 +/- 1.53% respectively, p < 0.05), a positive effect on cell count of PBMC (1395 +/- 151 x 10(3) and 1100 +/- 139 x 10(3) respectively, p < 0.05) and no effects on cell viability and its proliferation. More comprehensive trials are needed to clarify this effect of MPA.
ISSN:0392-9078