Specific allogeneic help by T lymphocytes from patients with systemic lupus erythematosus

• Published in: Clinical and experimental immunology Vol. 58; no. 1; pp. 21 - 28
• Main Authors: Hari Kumar, M K, Knight, R A, Snaith, M L
• Format: Journal Article
• Language: English
• Published: England 01.10.1984
• Subjects: Antibodies, Antinuclear - analysis; Antibodies, Viral - biosynthesis; Female; Humans; Immunoglobulin G - biosynthesis; influenza virus; Lupus Erythematosus, Systemic - immunology; Lymphocyte Cooperation; Lymphocyte Culture Test, Mixed; Male; Orthomyxoviridae - immunology; T-Lymphocytes - classification; T-Lymphocytes - immunology; T-Lymphocytes - radiation effects; T-Lymphocytes, Helper-Inducer - immunology
• ISSN: 0009-9104; 1365-2249

Unfractionated mononuclear cells from patients with systemic lupus erythematosus (SLE) immunized with influenza vaccines do not produce a secondary in vitro anti-influenza antibody response when challenged with virus antigen. Irradiated T lymphocytes from normal, disease control and from SLE donors whether vaccinated or not, help allogeneic normal non-T cells to produce specific anti-influenza antibody in vitro. Irradiated normal T cells, however, do not help allogeneic non-T cells from SLE donors. Non-irradiated T cells from 40% of the SLE patients, irrespective of whether or not they had been vaccinated, also provide specific help for MLC incompatible normal non-T cells in the influenza antibody response. This non-restricted interaction was not seen using non-irradiated T cells from any normal or disease control donor. No anti-DNA antibodies were produced in virus stimulated cultures of non-irradiated or irradiated SLE T cells with allogeneic normal non-T cells.