Differential involvement of non-specific suppressor T cells in two lethal murine malaria infections

The suppression of the contact sensitivity of oxazolone in murine malaria is shown to be mediated by non-specific T suppressor cells, but to a different extent in infection caused by two different species of parasite. Depletion of T suppressor cells in vivo and/or anti-Thy 1.2 treatment in vitro ind...

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Bibliographic Details
Published inClinical and experimental immunology Vol. 45; no. 2; pp. 433 - 438
Main Authors Lelchuk, R, Sprott, V M, Playfair, J H
Format Journal Article
LanguageEnglish
Published England 01.08.1981
Subjects
Animals
B-Lymphocytes - immunology
Dermatitis, Contact - immunology
Female
Immune Tolerance
Lymphocyte Depletion
Malaria - immunology
Mice
Mice, Inbred Strains
Oxazolone - immunology
Plasmodium berghei
T-Lymphocytes - immunology
T-Lymphocytes, Regulatory - immunology
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Summary:The suppression of the contact sensitivity of oxazolone in murine malaria is shown to be mediated by non-specific T suppressor cells, but to a different extent in infection caused by two different species of parasite. Depletion of T suppressor cells in vivo and/or anti-Thy 1.2 treatment in vitro indicated that in mice infected with P. berghei the suppressor effect was largely mediated by T cells. By contrast, in mice infected with a lethal strain of P. yoelii it was only partly due to T cells; B suppressor cells and/or macrophages may also be involved. However, depletion of T suppressor cells in vivo had no effect on the course of the parasitaemia or on the survival time. Therefore, we postulate that this kind of non-specific immunosuppression cannot be regarded as a major cause of lethality.
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ISSN:0009-9104
1365-2249