Colorectal cancer complicating ulcerative colitis: an institutional series

Ulcerative colitis predisposes to colorectal cancer: the risk increases along with disease duration and extension. Also some subsets of patients are at increased risk, namely patients with early onset of colitis, and patients with primary sclerosing cholangitis. Cancer complicating ulcerative coliti...

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Bibliographic Details
Published inJournal of experimental & clinical cancer research Vol. 18; no. 1; p. 29
Main Authors Fracasso, P, Assisi, D, Stigliano, V, Casale, V
Format Journal Article
LanguageEnglish
Published England 01.03.1999
Subjects
Adult
Colectomy
Colitis, Ulcerative - complications
Colonic Neoplasms - complications
Colonic Neoplasms - pathology
Colonic Neoplasms - surgery
Colorectal Neoplasms - complications
Combined Modality Therapy
Female
Humans
Male
Middle Aged
Neoplasm Staging
Rectal Neoplasms - complications
Rectal Neoplasms - pathology
Rectal Neoplasms - surgery
Risk Factors
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Summary:Ulcerative colitis predisposes to colorectal cancer: the risk increases along with disease duration and extension. Also some subsets of patients are at increased risk, namely patients with early onset of colitis, and patients with primary sclerosing cholangitis. Cancer complicating ulcerative colitis affects evenly all the colon, and is not located more frequently in the rectum and in the sigmoid colon, as well as the sporadic counterpart. Multiple cancers and cancers associated with high grade dysplasia are not infrequent in ulcerative colitis; for this reason, and for controlling the colitis, the treatment of choice is total colectomy, with or without colostomy. The prognosis of cancer complicating ulcerative colitis is similar to the sporadic counterpart. The Authors present a colon cancers series as a complication of colitis occurred at Regina Elena Cancer Institute of Rome, Italy, over the period 1975-1998.
ISSN:0392-9078