Effect of feeding Cuminum cyminum fruits, Thymus vulgaris leaves or their mixture to rats

Cuminum cyminum fruits and T. vulgaris leaves were fed to male Wistar rats at 2% or 10% of standard diet for 6 w. A mixture (5% +5%) of the 2 plants was also fed to rats for a similar period. Diets containing 2% C. cyminum fruits, 2% or 10% T. vulgaris leaves were not toxic to rats. Impairment of gr...

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Bibliographic Details
Published inVeterinary and human toxicology Vol. 44; no. 2; p. 67
Main Authors Haroun, E M, Mahmoud, O M, Adam, S E I
Format Journal Article
LanguageEnglish
Published United States 01.04.2002
Subjects
Administration, Oral
Animals
Cuminum - toxicity
Diet
Drug Interactions
Fruit
Kidney - pathology
Leukopenia - chemically induced
Liver - pathology
Male
Plant Leaves
Plant Preparations
Rats
Rats, Wistar
Thymus Plant - toxicity
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Summary:Cuminum cyminum fruits and T. vulgaris leaves were fed to male Wistar rats at 2% or 10% of standard diet for 6 w. A mixture (5% +5%) of the 2 plants was also fed to rats for a similar period. Diets containing 2% C. cyminum fruits, 2% or 10% T. vulgaris leaves were not toxic to rats. Impairment of growth and enterohepatonephropathy were observed in the rats fed a diet containing 10% C. cyminum fruits. These changes were also seen in the rats fed the mixture of the 2 plants and were accompanied by leukopenia, anemia and increases in serum AST activity and urea and by decreased total protein and albumin levels.
ISSN:0145-6296