Non-alcoholic fatty liver disease: treatment options based on pathogenic considerations

NASH is a frequent liver disease that develops in close association with IR and may progress to cirrhosis. Exclusion of excessive alcohol consumption as well as of other liver diseases and liver histology are required for diagnosis. Progress in the understanding of the pathophysiology of NASH allows...

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Bibliographic Details
Published inSwiss medical weekly Vol. 132; no. 35-36; p. 493
Main Authors Oneta, Carl M, Dufour, Jean-François
Format Journal Article
LanguageEnglish
Published Switzerland 07.09.2002
Subjects
Biopsy, Needle
Drug Therapy, Combination
Fatty Liver - complications
Fatty Liver - mortality
Fatty Liver - pathology
Fatty Liver - therapy
Female
Humans
Insulin Resistance
Liver Cirrhosis - etiology
Liver Cirrhosis - mortality
Liver Cirrhosis - pathology
Liver Cirrhosis - therapy
Liver Function Tests
Liver Transplantation
Male
Necrosis
Prognosis
Risk Assessment
Severity of Illness Index
Survival Rate
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Summary:NASH is a frequent liver disease that develops in close association with IR and may progress to cirrhosis. Exclusion of excessive alcohol consumption as well as of other liver diseases and liver histology are required for diagnosis. Progress in the understanding of the pathophysiology of NASH allows interesting therapeutic considerations. It is logical to treat the associated metabolic conditions to influence the disease activity and progression. In view of promising preliminary data, several drugs are currently used in clinical trials.
ISSN:1424-7860