Alpha-L-fucosidase enzyme in the prediction of colorectal cancer patients at high risk of tumor recurrence

The aim of this study was to examine the prognostic value of the alpha-L-fucosidase enzyme to determine whether it can help in the early recognition of colorectal cancer cases at high risk of tumor recurrence. One hundred and twenty-three colorectal carcinoma patients treated by curative surgery wer...

Full description

Saved in:
Bibliographic Details
Published inCancer detection and prevention Vol. 24; no. 2; p. 143
Main Authors Fernández-Rodríguez, J, Ayude, D, de la Cadena, M P, Martínez-Zorzano, V S, de Carlos, A, Caride-Castro, A, de Castro, G, Rodríguez-Berrocal, F J
Format Journal Article
LanguageEnglish
Published England 2000
Subjects
Adult
Aged
Aged, 80 and over
alpha-L-Fucosidase - metabolism
Colorectal Neoplasms - enzymology
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Female
Humans
Male
Middle Aged
Neoplasm Invasiveness
Neoplasm Recurrence, Local - enzymology
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
Prognosis
Risk Factors
Survival Analysis
Online AccessGet more information

Cover

More Information
Summary:The aim of this study was to examine the prognostic value of the alpha-L-fucosidase enzyme to determine whether it can help in the early recognition of colorectal cancer cases at high risk of tumor recurrence. One hundred and twenty-three colorectal carcinoma patients treated by curative surgery were studied. The alpha-L-fucosidase activity was assayed in the tumor and in normal mucosa from each patient using a fluorometric method. Seven other clinical and pathologic features were also studied. To evaluate the impact of each variable over the disease-free interval, a postoperative 30-month follow-up of patients was performed, and a statistical survival analysis was carried out. The recurrence appearance was higher when the relative decrease of alpha-L-fucosidase activity was more than 52% (log-rank test, P = .0261). The results of this work indicate that alpha-L-fucosidase activity appears to be a good independent prognostic factor of tumoral recurrence in colorectal carcinoma.
ISSN:0361-090X