The efficacy of prophylactic administration of SBT/ABPC for postoperative infection in neurosurgical operations

We investigated prospectively the efficacy of sulbactam sodium/ampicillin sodium (SBT/ABPC), which is a combination drug of ampicillin and beta-lactamase inhibitor, as a preventive drug against postoperative infection in the field of neurological surgery. One hundred and six patients were given SBT/...

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Published inNō shinkei geka Vol. 30; no. 10; p. 1075
Main Authors Idomari, Koji, Sakai, Keiichi, Takasawa, Hisayoshi, Miyairi, Yosuke, Yako, Takehiro, Murata, Takahiro, Sakamoto, Michio, Nitta, Junpei, Hongo, Kazuhiro, Kobayashi, Sigeaki, Aoki, Toshiki, Kobayashi, Satoshi
Format Journal Article
LanguageJapanese
Published Japan 01.10.2002
Subjects
Adolescent
Adult
Aged
Ampicillin - therapeutic use
Antibiotic Prophylaxis
Brain Neoplasms - surgery
Cerebrovascular Disorders - surgery
Drug Therapy, Combination - therapeutic use
Female
Humans
Infusions, Intravenous
Male
Middle Aged
Neurosurgical Procedures
Prospective Studies
Sulbactam - therapeutic use
Surgical Wound Infection - prevention & control
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Summary:We investigated prospectively the efficacy of sulbactam sodium/ampicillin sodium (SBT/ABPC), which is a combination drug of ampicillin and beta-lactamase inhibitor, as a preventive drug against postoperative infection in the field of neurological surgery. One hundred and six patients were given SBT/ABPC as follows: Before anesthetic induction at surgery, 1.5 g of SBT/ABPC was administrated by intravenous drip infusion, and further doses were continued at 12-hour intervals for 5 to 7 days. We assessed postoperative infection, type of surgery, duration of operation, and amount of hemorrhage. Search for related side effects and bacteriological examinations of the nasal cavity and throat before and after treatment were performed. The result was that postoperative infection was found in none of the patients. Adverse reactions due to SBT/ABPC such as apparent skin symptoms or gastrointestinal symptoms were not observed. Considering infections highly resistant to MRSA, SBT/ABPC would be effective to prevent postoperative infection in neurosurgical operations and could be used safely.
ISSN:0301-2603