Measuring the efficacy of rhBMP-2 to regenerate bone: a radiographic study using a commercially available software program

• Published in: The International journal of periodontics & restorative dentistry Vol. 24; no. 6; p. 579
• Main Authors: Bianchi, Jorge, Fiorellini, Joseph P, Howell, T Howard, Sekler, Julio, Curtin, Hugh, Nevins, Marc L, Friedland, Bernard
• Format: Journal Article
• Language: English
• Published: United States 01.12.2004
• Subjects: Alveolar Bone Loss - surgery; Alveolar Process - diagnostic imaging; Alveolar Process - drug effects; Alveolar Ridge Augmentation; Bone Density - drug effects; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins - therapeutic use; Bone Regeneration - drug effects; Female; Follow-Up Studies; Humans; Image Processing, Computer-Assisted - methods; Male; Maxilla - diagnostic imaging; Maxilla - drug effects; Maxilla - surgery; Middle Aged; Reproducibility of Results; Retrospective Studies; Software; Tomography, X-Ray Computed; Transforming Growth Factor beta - therapeutic use
• ISSN: 0198-7569

This radiographic study evaluated the efficacy of different concentrations of rhBMP-2 to regenerate bone in alveolar defects in the anterior maxilla. The study was performed using reasonably standardized CT examinations and the Simplant program. The radiographic measurements were further refined by careful standardization of the measured regions of interest. There was a statistically significant difference in bone formation between subjects treated with a concentration of 1.5 mg/mL rhBMP-2 compared with each of the other groups. There was no statistically significant difference in bone volume between any of the other groups. None of the groups showed a loss in bone volume.