Local recurrence after mastectomy or breast-conserving surgery and radiation

Approximately 10% to 15% of patients with stage I/II invasive breast cancer will develop a clinically isolated local recurrence. The standard management of an ipsilateral breast tumor recurrence following breast-conserving surgery and radiation is salvage mastectomy, while local excision and radiati...

Full description

Saved in:
Bibliographic Details
Published inOncology (Williston Park, N.Y.) Vol. 14; no. 11; p. 1561
Main Authors Freedman, G M, Fowble, B L
Format Journal Article
LanguageEnglish
Published United States 01.11.2000
Subjects
Breast Neoplasms - pathology
Breast Neoplasms - radiotherapy
Breast Neoplasms - surgery
Female
Humans
Incidence
Mastectomy, Segmental
Neoplasm Recurrence, Local - diagnosis
Neoplasm Recurrence, Local - epidemiology
Neoplasm Recurrence, Local - therapy
Neoplasm Staging
Prognosis
Risk Factors
Salvage Therapy
Online AccessGet more information

Cover

More Information
Summary:Approximately 10% to 15% of patients with stage I/II invasive breast cancer will develop a clinically isolated local recurrence. The standard management of an ipsilateral breast tumor recurrence following breast-conserving surgery and radiation is salvage mastectomy, while local excision and radiation are optimal treatment of a chest wall recurrence following initial mastectomy. Although there are few data regarding the efficacy of systemic therapy after isolated local relapse, chemotherapy and/or hormonal therapy should be considered for most patients because of the high risk of subsequent distant relapse. However, local relapse does not always herald distant metastases. A prolonged interval between initial treatment and local recurrence is the most important prognostic factor for subsequent outcome, and when combined with other favorable characteristics, can predict 5-year survival rates of 70% or higher.
ISSN:0890-9091