Angiogenesis, angiogenic factor expression and prognosis of bladder cancer

Angiogenesis is the process by which tumours induce a blood supply from their surrounding tissues and it has been shown to be necessary for tumour growth. Evidence is accumulating for both the prognostic usefulness of measures of angiogenesis and its potential as a target for anticancer therapy. Thi...

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Bibliographic Details
Published inAnticancer research Vol. 21; no. 6B; p. 4355
Main Authors Streeter, E H, Crew, J P
Format Journal Article
LanguageEnglish
Published Greece 01.11.2001
Subjects
Angiogenesis Inducing Agents - biosynthesis
DNA-Binding Proteins - biosynthesis
Endothelial Growth Factors - biosynthesis
Growth Substances - biosynthesis
Humans
Hypoxia-Inducible Factor 1
Hypoxia-Inducible Factor 1, alpha Subunit
Lymphokines - biosynthesis
Neovascularization, Pathologic - metabolism
Nuclear Proteins - biosynthesis
Prognosis
Thymidine Phosphorylase - metabolism
Transcription Factors
Urinary Bladder Neoplasms - blood supply
Urinary Bladder Neoplasms - metabolism
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
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Summary:Angiogenesis is the process by which tumours induce a blood supply from their surrounding tissues and it has been shown to be necessary for tumour growth. Evidence is accumulating for both the prognostic usefulness of measures of angiogenesis and its potential as a target for anticancer therapy. This review discusses the evidence concerning the association between angiogenesis and bladder cancer, focusing on the mechanisms behind the angiogenic process and the quantification of factors believed to be involved, relating these clinically to their prognostic use and to the antiangiogenic strategies so far described in vitro and in vivo.
ISSN:0250-7005
1791-7530