Zinc effect on the in vitro formation of calcium phosphates: relevance to clinical inhibition of calculus formation

To determine the effect of zinc on the in vitro formation of calcium phosphates and its relevance to calculus inhibition. Different types of calcium phosphate phases (amorphous calcium phosphate, ACP; dicalcium phosphate dihydrate, DCPD; octacalcium phosphate, OCP; and carbonate hydoxyapatite, CHA)...

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Bibliographic Details
Published inAmerican journal of dentistry Vol. 12; no. 2; p. 65
Main Authors LeGeros, R Z, Bleiwas, C B, Retino, M, Rohanizadeh, R, LeGeros, J P
Format Journal Article
LanguageEnglish
Published United States 01.04.1999
Subjects
Calcium Phosphates - chemistry
Crystallization
Dental Calculus - chemistry
Dental Calculus - prevention & control
Humans
Hydrogen-Ion Concentration
Microscopy, Electron, Scanning
Solutions
Spectroscopy, Fourier Transform Infrared
Temperature
X-Ray Diffraction
Zinc - chemistry
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Summary:To determine the effect of zinc on the in vitro formation of calcium phosphates and its relevance to calculus inhibition. Different types of calcium phosphate phases (amorphous calcium phosphate, ACP; dicalcium phosphate dihydrate, DCPD; octacalcium phosphate, OCP; and carbonate hydoxyapatite, CHA) were precipitated from solutions containing increasing concentrations of zinc (Zn) ions. The precipitates were characterized using x-ray diffraction, infrared absorption spectroscopy, and scanning electron microscopy. The presence of Zn ions affected the type and amount of calcium phosphate phases formed. Zn, even at concentrations as low as 0.1 mM/L, inhibited the crystal growth of DCPD, OCP and AP; and, at higher concentrations (0.5 mM to 2 mM/L), promoted the formation of amorphous calcium phosphate, ACP, or Zn-substituted tricalcium phosphate (beta-TCP) depending on the reaction pH and temperature.
ISSN:0894-8275