Interaction of zinc with antidepressants in the forced swimming test in mice

Recent preclinical data have suggested that glutamate NMDA receptor may be involved in the mechanism of action of antidepressant treatments. Functional antagonists of the NMDA receptor complex exhibit an antidepressant-like effect in animal tests that predict antidepressant activity and in animal mo...

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Published inPolish journal of pharmacology Vol. 54; no. 6; p. 681
Main Authors Szewczyk, Bernadeta, Brański, Piotr, Wierońska, Joanna M, Pałucha, Agnieszka, Pilc, Andrzej, Nowak, Gabriel
Format Journal Article
LanguageEnglish
Published Poland 01.11.2002
Subjects
Animals
Antidepressive Agents - pharmacology
Antidepressive Agents - therapeutic use
Depression - drug therapy
Drug Interactions - physiology
Drug Therapy, Combination
Immobilization - physiology
Male
Mice
Motor Activity - drug effects
Motor Activity - physiology
Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors
Swimming - physiology
Zinc - pharmacology
Zinc - therapeutic use
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Summary:Recent preclinical data have suggested that glutamate NMDA receptor may be involved in the mechanism of action of antidepressant treatments. Functional antagonists of the NMDA receptor complex exhibit an antidepressant-like effect in animal tests that predict antidepressant activity and in animal models of depression. Zinc, a very potent inhibitor of the NMDA receptor, is active in the forced swimming test in rats and mice. The present study investigated the interaction of zinc with antidepressants in the forced swimming test in mice. Mice were injected with imipramine or citalopram alone and in combination with zinc. Low, ineffective per se doses of imipramine and citalopram administered together with low, ineffective doses of zinc were active in this test. The present data support the notion that inhibition of the NMDA receptor participates in an antidepressant action, and further demonstrate particular role of zinc in this activity.
ISSN:1230-6002