1,5-anhydro-D-glucitol: a novel marker of glucose excursions

In recent years a great deal of discussion has focused on postprandial hyperglycaemia as a risk factor for cardiovascular mortality. Routinely used parameters of metabolic control such as fasting plasma glucose (FPG) and HbA1c are not useful for determination of daily glucose excursions. 1,5-Anhydro...

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Published inInternational journal of clinical practice. Supplement no. 129; p. 40
Main Authors Dworacka, Marzena, Winiarska, Hanna, Szymanska, Malgorzata, Kuczynski, Sebastian, Szczawinska, Krystyna, Wierusz-Wysocka, Bogna
Format Journal Article
LanguageEnglish
Published England 01.07.2002
Subjects
Biomarkers - analysis
Blood Glucose - analysis
Deoxyglucose - blood
Diabetes Mellitus, Type 2 - blood
Diabetic Angiopathies - prevention & control
Glycated Hemoglobin A - analysis
Humans
Hyperglycemia - diagnosis
Postprandial Period - physiology
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Summary:In recent years a great deal of discussion has focused on postprandial hyperglycaemia as a risk factor for cardiovascular mortality. Routinely used parameters of metabolic control such as fasting plasma glucose (FPG) and HbA1c are not useful for determination of daily glucose excursions. 1,5-Anhydro-D-glucitol (1,5-AG) in human plasma has been proposed for several years as a short-term, retrospective marker of glycaemic control and seems to be the most suitable parameter for monitoring glucose excursions. The plasma level of 1,5-AG reflects acute episodes of hyperglycaemia more sensitively than HbA1c does and is correlated with FPG and postprandial hyperglycaemic peaks. The maximal glycaemic value observed in a patient ultimately determines the plasma 1,5-AG level. 1,5-AG could be helpful in detection of hyperglycaemic excursions, even in those patients with diabetes who self-monitor blood glucose and in those patients who are monitored routinely for FPG and HbA1c. In non-diabetic patients the plasma 1,5-AG level may serve as a screening marker for postprandial hyperglycaemia-associated cardiovascular risk.
ISSN:1368-504X