Effect of eprosartan on left ventricular diastolic function and cerebral hemodynamics in patients with hypertension

Eprosartan (600-1200 mg/day) was given for 4 weeks to 28 patients aged 32-62 years with stage II-III hypertension (WHO, 1999). Left ventricular diastolic function and cerebral blood flow were assessed by echocardiography and ultrasound dopplerography. Treatment with eprosartan was associated with im...

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Bibliographic Details
Published inKardiologiia Vol. 42; no. 10; p. 41
Main Authors Markova, L I, Radzevich, A E, Koren'kov, V V, Belavina, N I, Griabina, N A, Zharova, O Iu
Format Journal Article
LanguageRussian
Published Russia (Federation) 2002
Subjects
Acrylates - administration & dosage
Acrylates - pharmacology
Acrylates - therapeutic use
Adult
Antihypertensive Agents - administration & dosage
Antihypertensive Agents - pharmacology
Antihypertensive Agents - therapeutic use
Carotid Artery, Internal - diagnostic imaging
Cerebrovascular Circulation - drug effects
Diastole - drug effects
Echocardiography
Female
Follow-Up Studies
Homeostasis
Humans
Hypertension - drug therapy
Hypertension - physiopathology
Imidazoles - administration & dosage
Imidazoles - pharmacology
Imidazoles - therapeutic use
Male
Middle Aged
Models, Cardiovascular
Thiophenes
Time Factors
Treatment Outcome
Ultrasonography, Doppler, Transcranial
Ventricular Function, Left - drug effects
Vertebral Artery - diagnostic imaging
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Summary:Eprosartan (600-1200 mg/day) was given for 4 weeks to 28 patients aged 32-62 years with stage II-III hypertension (WHO, 1999). Left ventricular diastolic function and cerebral blood flow were assessed by echocardiography and ultrasound dopplerography. Treatment with eprosartan was associated with improvements of impaired left ventricular diastolic function, structural and functional state of the heart, venous outflow from cerebral vessels, and restoration of unpaired autoregulation of cerebral blood flow. All these phenomena could potentially lead to normalization of cerebral tissue perfusion and stabilization of cerebral blood flow.
ISSN:0022-9040