Acetylcholine is released from in vitro cat carotid bodies during hypoxic stimulation

Previous pharmacological, immunocytochemical, electrophysiological, and microfluorometric studies have suggested that acetylcholine (ACh) is a critically important excitatory transmitter in the chemotransduction of hypoxia by the cat carotid body (CB). With the use of HPLC this study shows that the...

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Bibliographic Details
Published inAdvances in experimental medicine and biology Vol. 475; p. 485
Main Authors Fitzgerald, R S, Shirahata, M, Wang, H Y
Format Journal Article
LanguageEnglish
Published United States 2000
Subjects
Acetylcholine - metabolism
Animals
Atropine - pharmacology
Carotid Body - drug effects
Carotid Body - metabolism
Cats
Gallamine Triethiodide - pharmacology
Hypoxia - physiopathology
In Vitro Techniques
Mecamylamine - pharmacology
Parasympatholytics - pharmacology
Pirenzepine - analogs & derivatives
Pirenzepine - pharmacology
Receptor, Muscarinic M2
Receptors, Muscarinic - drug effects
Receptors, Muscarinic - physiology
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Summary:Previous pharmacological, immunocytochemical, electrophysiological, and microfluorometric studies have suggested that acetylcholine (ACh) is a critically important excitatory transmitter in the chemotransduction of hypoxia by the cat carotid body (CB). With the use of HPLC this study shows that the in vitro cat CB releases ACh under normoxic conditions; this release is increased when the CB is challenged with hypoxia. The preliminary observation that greater amounts of ACh are liberated in the presence of gallamine and AFDX116 suggests the presence of functioning M2 muscarinic receptors on the glomus cells of the CB.
ISSN:0065-2598