The tethered aminohydroxylation (TA) reaction

Since Sharpless' discovery of the asymmetric aminohydroxylation (AA) reaction, a major challenge for chemists has been to find ways of controlling the regio- and stereochemical outcome of this important reaction. Detailed herein is a review of our novel approach towards gaining reliable and pre...

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Published inOrganic & biomolecular chemistry Vol. 1; no. 12; pp. 2025 - 2028
Main Authors Donohoe, Timothy J, Johnson, Peter D, Pye, Richard J
Format Journal Article
LanguageEnglish
Published England 21.06.2003
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Summary:Since Sharpless' discovery of the asymmetric aminohydroxylation (AA) reaction, a major challenge for chemists has been to find ways of controlling the regio- and stereochemical outcome of this important reaction. Detailed herein is a review of our novel approach towards gaining reliable and predictable regio- and stereocontrol through the use of a tethered carbamate to promote an intramolecular AA reaction, along with a description of the mechanism proposed for this new methodology.
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ISSN:1477-0520
DOI:10.1039/b305189g