Effect of endothelin-1 on DNA synthesis in the myocardium of albino rats during early postnatal ontogeny
Effect of intraperitoneal injection of endothelin-1 on DNA synthesis in the myocardium of newborn albino rats was studied by(3)H-thymidine autoradiography. Endothelin-1 injected in a single dose of 10 microg/kg stimulated proliferative processes: the index of labeled nuclei and labeling intensity in...
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Published in | Bulletin of experimental biology and medicine Vol. 130; no. 12; pp. 1144 - 1146 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.12.2000
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Subjects | |
Online Access | Get full text |
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Summary: | Effect of intraperitoneal injection of endothelin-1 on DNA synthesis in the myocardium of newborn albino rats was studied by(3)H-thymidine autoradiography. Endothelin-1 injected in a single dose of 10 microg/kg stimulated proliferative processes: the index of labeled nuclei and labeling intensity increased. Repeated (5 times) administration of endothelin-1 in doses of 1 and 10 microg/kg increased labeling intensity, but did not change the index of labeled nuclei. The data suggest that endothelins are involved in morphogenesis of the myocardium during the early postnatal ontogeny. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0007-4888 |
DOI: | 10.1023/A:1017563414203 |