Effect of endothelin-1 on DNA synthesis in the myocardium of albino rats during early postnatal ontogeny

Effect of intraperitoneal injection of endothelin-1 on DNA synthesis in the myocardium of newborn albino rats was studied by(3)H-thymidine autoradiography. Endothelin-1 injected in a single dose of 10 microg/kg stimulated proliferative processes: the index of labeled nuclei and labeling intensity in...

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Published inBulletin of experimental biology and medicine Vol. 130; no. 12; pp. 1144 - 1146
Main Authors Sazonova, E N, Sazonov, O A, Lebed'ko, O A, Pikalova, V M, Timoshin, S S, Rubina, A Y
Format Journal Article
LanguageEnglish
Published United States 01.12.2000
Subjects
Animals
Animals, Newborn
Autoradiography
Cell Division - drug effects
DNA - biosynthesis
Endothelin-1 - administration & dosage
Endothelin-1 - pharmacology
Heart - drug effects
Heart - growth & development
Myocardium - cytology
Myocardium - metabolism
Rats
Thymidine - metabolism
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Summary:Effect of intraperitoneal injection of endothelin-1 on DNA synthesis in the myocardium of newborn albino rats was studied by(3)H-thymidine autoradiography. Endothelin-1 injected in a single dose of 10 microg/kg stimulated proliferative processes: the index of labeled nuclei and labeling intensity increased. Repeated (5 times) administration of endothelin-1 in doses of 1 and 10 microg/kg increased labeling intensity, but did not change the index of labeled nuclei. The data suggest that endothelins are involved in morphogenesis of the myocardium during the early postnatal ontogeny.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0007-4888
DOI:10.1023/A:1017563414203