Increased polyploid incidence is associated with abnormal copper accumulation in the liver of LEC mutant rat
Long-Evans Cinnamon (LEC) rats are deleted at the p-type copper transport ATPase gene (Atp7b), so that they exhibit abnormal hepatic copper concentration. In this study, it was confirmed that LEC rat liver possesses a feature of increase in polyploid. Furthermore, a segregation analysis using backcr...
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Published in | Research communications in molecular pathology and pharmacology Vol. 107; no. 1-2; p. 129 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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United States
2000
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Abstract | Long-Evans Cinnamon (LEC) rats are deleted at the p-type copper transport ATPase gene (Atp7b), so that they exhibit abnormal hepatic copper concentration. In this study, it was confirmed that LEC rat liver possesses a feature of increase in polyploid. Furthermore, a segregation analysis using backcrosses between LEC and F344 normal rats showed that the increased polyploid incidence is strongly associated with excessive copper content in their liver. These results should demonstrate that copper cytotoxicity leads to the impairment of mitotic progression, resulting in the increase of polyploid in the liver of LEC rats. |
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AbstractList | Long-Evans Cinnamon (LEC) rats are deleted at the p-type copper transport ATPase gene (Atp7b), so that they exhibit abnormal hepatic copper concentration. In this study, it was confirmed that LEC rat liver possesses a feature of increase in polyploid. Furthermore, a segregation analysis using backcrosses between LEC and F344 normal rats showed that the increased polyploid incidence is strongly associated with excessive copper content in their liver. These results should demonstrate that copper cytotoxicity leads to the impairment of mitotic progression, resulting in the increase of polyploid in the liver of LEC rats. |
Author | Yamada, T Moralejo, D H Mochizuki, H Sogawa, K Matsumoto, K Muramatsu, Y |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11334362$$D View this record in MEDLINE/PubMed |
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Snippet | Long-Evans Cinnamon (LEC) rats are deleted at the p-type copper transport ATPase gene (Atp7b), so that they exhibit abnormal hepatic copper concentration. In... |
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SubjectTerms | Animals Copper - metabolism Copper - toxicity Female Flow Cytometry Hepatocytes - ultrastructure Heterozygote Homozygote Liver - cytology Liver - metabolism Male Mutation Polyploidy Rats Rats, Inbred F344 Rats, Inbred LEC Rats, Mutant Strains |
Title | Increased polyploid incidence is associated with abnormal copper accumulation in the liver of LEC mutant rat |
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