Increased polyploid incidence is associated with abnormal copper accumulation in the liver of LEC mutant rat

Long-Evans Cinnamon (LEC) rats are deleted at the p-type copper transport ATPase gene (Atp7b), so that they exhibit abnormal hepatic copper concentration. In this study, it was confirmed that LEC rat liver possesses a feature of increase in polyploid. Furthermore, a segregation analysis using backcr...

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Bibliographic Details
Published inResearch communications in molecular pathology and pharmacology Vol. 107; no. 1-2; p. 129
Main Authors Muramatsu, Y, Yamada, T, Moralejo, D H, Mochizuki, H, Sogawa, K, Matsumoto, K
Format Journal Article
LanguageEnglish
Published United States 2000
Subjects
Animals
Copper - metabolism
Copper - toxicity
Female
Flow Cytometry
Hepatocytes - ultrastructure
Heterozygote
Homozygote
Liver - cytology
Liver - metabolism
Male
Mutation
Polyploidy
Rats
Rats, Inbred F344
Rats, Inbred LEC
Rats, Mutant Strains
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Summary:Long-Evans Cinnamon (LEC) rats are deleted at the p-type copper transport ATPase gene (Atp7b), so that they exhibit abnormal hepatic copper concentration. In this study, it was confirmed that LEC rat liver possesses a feature of increase in polyploid. Furthermore, a segregation analysis using backcrosses between LEC and F344 normal rats showed that the increased polyploid incidence is strongly associated with excessive copper content in their liver. These results should demonstrate that copper cytotoxicity leads to the impairment of mitotic progression, resulting in the increase of polyploid in the liver of LEC rats.
ISSN:1078-0297