Disorders in restructuring of T-cell receptor gamma-chain in malignant skin lymphomas

Disorders in restructuring of T-cell receptor gamma-chain in DNA from skin biopsy specimens and peripheral blood lymphocyte of patients with malignant skin lymphomas at different stages of the disease were detected by PCR. Nucleotide sequences of monoclonal T-cell receptors were determined. The stud...

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Published inBulletin of experimental biology and medicine Vol. 138; no. 2; pp. 179 - 181
Main Authors Savvateeva, M V, Savina, M I, Markusheva, L I, Samsonov, V A, Toguzov, R T
Format Journal Article
LanguageEnglish
Published United States 01.08.2004
Subjects
Adult
Aged
Base Sequence
DNA, Neoplasm - analysis
Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor - genetics
Humans
Lymphocytes - chemistry
Lymphoma - genetics
Lymphoma - immunology
Lymphoma - pathology
Middle Aged
Neoplasm Staging
Polymerase Chain Reaction
Sensitivity and Specificity
Skin - chemistry
Skin Neoplasms - genetics
Skin Neoplasms - immunology
Skin Neoplasms - pathology
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Summary:Disorders in restructuring of T-cell receptor gamma-chain in DNA from skin biopsy specimens and peripheral blood lymphocyte of patients with malignant skin lymphomas at different stages of the disease were detected by PCR. Nucleotide sequences of monoclonal T-cell receptors were determined. The study showed that DNA sequences from the skin and lymphocytes did not coincide in some cases.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-4888
DOI:10.1023/B:BEBM.0000048382.03906.32