Six-week treatment with Ukrain in rabbits. Part I: Morphological parameters

This study was performed to evaluate the effect of 6-week treatment with Ukrain in doses of 0.3, 1.5 and 3.0 mg/kg i.v. on the morphological and biochemical parameters of peripheral blood and morphology of body organs in rabbits. Ukrain application did not change the body organs and total body weigh...

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Bibliographic Details
Published inDrugs under experimental and clinical research Vol. 24; no. 5-6; p. 295
Main Authors Jagiello-Wójtowicz, E, Kleinrok, Z, Feldo, M, Chodkowska, A, Szponar, J, Urbanska, E M
Format Journal Article
LanguageEnglish
Published Switzerland 1998
Subjects
Alkaloids - toxicity
Animals
Antineoplastic Agents - toxicity
Berberine Alkaloids
Body Weight - drug effects
Dose-Response Relationship, Drug
Female
Male
Organ Size - drug effects
Phenanthridines
Rabbits
Time Factors
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Summary:This study was performed to evaluate the effect of 6-week treatment with Ukrain in doses of 0.3, 1.5 and 3.0 mg/kg i.v. on the morphological and biochemical parameters of peripheral blood and morphology of body organs in rabbits. Ukrain application did not change the body organs and total body weight. The drug did not affect biochemical parameters of peripheral blood, except for a minor reduction in the total plasma level and increases in serum uric acid and urea indicating enhanced catabolism of proteins. The peripheral erythrocyte and leukocyte counts were not altered, whereas the percentages of lymphocytes, monocytes, and eozynophils were increased after higher doses of Ukrain. An increase in rod neutrophils and a decrease in the percentage of segmented neutrophils were also noted. These observations indicate a lack of organ toxicity following long-term treatment with Ukrain.
ISSN:0378-6501