Fluorescent sodium ion indicators based on the 1,7-diaza-15-crown-5 system

A series of novel sodium ion-sensitive fluorescent reagents suitable for biological applications is described. The chelator nitrogen atom substituents affect the selectivity and affinity of cation binding, while the nature of the fluorophore determines the type of fluorescent response to metal ion c...

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 14; no. 21; pp. 5313 - 5316
Main Authors Martin, Vladimir V, Rothe, Anca, Diwu, Zhenjun, Gee, Kyle R
Format Journal Article
LanguageEnglish
Published England 01.11.2004
Subjects
Animals
Cations, Monovalent
Crown Ethers - chemical synthesis
Crown Ethers - chemistry
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Ionophores - chemical synthesis
Ionophores - chemistry
Mice
NIH 3T3 Cells
Sodium - analysis
Solutions
Spectrometry, Fluorescence
Water
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Summary:A series of novel sodium ion-sensitive fluorescent reagents suitable for biological applications is described. The chelator nitrogen atom substituents affect the selectivity and affinity of cation binding, while the nature of the fluorophore determines the type of fluorescent response to metal ion chelation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0960-894X
DOI:10.1016/j.bmcl.2004.08.022