Reversal of ethylene glycol-induced nephrotoxicosis in a dog

Ethylene glycol-induced nephrotoxicosis was diagnosed in a dog with acute renal failure. Histologically, the dog had proximal tubular degeneration and necrosis, intraluminal calcium oxalate crystals, generally intact tubular basement membranes, and evidence of tubular regeneration. After 20 days of...

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Bibliographic Details
Published inJournal of the American Veterinary Medical Association Vol. 191; no. 11; p. 1433
Main Authors Fox, L E, Grauer, G F, Dubielzig, R R, Bjorling, D E
Format Journal Article
LanguageEnglish
Published United States 01.12.1987
Subjects
Acute Kidney Injury - chemically induced
Acute Kidney Injury - pathology
Acute Kidney Injury - therapy
Acute Kidney Injury - veterinary
Animals
Dog Diseases - chemically induced
Dog Diseases - pathology
Dog Diseases - therapy
Dogs
Ethylene Glycol
Ethylene Glycols - poisoning
Male
Peritoneal Dialysis - veterinary
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Summary:Ethylene glycol-induced nephrotoxicosis was diagnosed in a dog with acute renal failure. Histologically, the dog had proximal tubular degeneration and necrosis, intraluminal calcium oxalate crystals, generally intact tubular basement membranes, and evidence of tubular regeneration. After 20 days of peritoneal dialysis and diuresis, renal function was adequate to maintain homeostasis without supportive care. Nine weeks after onset of the ethylene glycol-induced renal failure, the dog's kidneys were histologically and functionally normal.
ISSN:0003-1488