Islet amyloid polypeptide in Psammomys obesus: lack of correlation between insulin resistance and plasma IAPP levels

Sand rats (Psammomys obesus) develop insulin resistance and diabetes when given a standard laboratory diet. We have examined the presence of islet amyloid polypeptide (IAPP), or amylin, in these animals. IAPP is present in the beta-cells of pancreatic islets, its localization and intensity of immuno...

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Published inCellular and molecular biology (Noisy-le-Grand, France) Vol. 40; no. 4; p. 535
Main Authors Duhault, J, Boulanger, M, Espinal, J, Marquié, G, Petkov, P, Donev, S, Jablenska, R, Popov, A
Format Journal Article
LanguageEnglish
Published France 01.06.1994
Subjects
Amyloid - blood
Animals
Blood Glucose
Diabetes Mellitus - physiopathology
Disease Models, Animal
Female
Gerbillinae
Insulin - blood
Insulin Resistance
Islet Amyloid Polypeptide
Islets of Langerhans - pathology
Male
Pancreas - chemistry
Pancreas - pathology
Rats
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Summary:Sand rats (Psammomys obesus) develop insulin resistance and diabetes when given a standard laboratory diet. We have examined the presence of islet amyloid polypeptide (IAPP), or amylin, in these animals. IAPP is present in the beta-cells of pancreatic islets, its localization and intensity of immuno-reactivity are, thus, similar to that of insulin. In insulin resistant Psammomys obesus, insulin and IAPP immuno-reactivity in pancreas are markedly decreased, plasma insulin levels are 20-fold higher than in controls but IAPP levels are not different from those of normal animals. Therefore, insulin resistance in Psammomys obesus does not appear to result from an elevated plasma IAPP level nor from development of amyloid deposits.
ISSN:0145-5680