Prostate-specific antigen. Its discovery and biochemical characteristics

The search for a more sensitive and specific marker for prostate cancer as well as for use in forensic investigations led to the discovery of PSA. Utilization of the purified protein resulted in the development of many immunoassays that are now in widespread use and have been applied successfully to...

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Bibliographic Details
Published inUrologic clinics of North America Vol. 24; no. 2; p. 253
Main Authors Sokoll, L J, Chan, D W
Format Journal Article
LanguageEnglish
Published United States 01.05.1997
Subjects
Humans
Male
Prostate-Specific Antigen - blood
Prostate-Specific Antigen - chemistry
Prostate-Specific Antigen - isolation & purification
Prostatic Neoplasms - diagnosis
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Summary:The search for a more sensitive and specific marker for prostate cancer as well as for use in forensic investigations led to the discovery of PSA. Utilization of the purified protein resulted in the development of many immunoassays that are now in widespread use and have been applied successfully to the detection and monitoring of prostate cancer. Subsequent investigation into the biochemical characteristics of PSA revealed free and complexed forms of PSA in serum whose measurement now may provide additional clinical benefit. Further research into the molecular and biochemical properties of PSA as well as improvements in measurement techniques no doubt will lead to new applications and enhanced clinical use for this important tumor marker.
ISSN:0094-0143
1558-318X
DOI:10.1016/S0094-0143(05)70370-0