New active analogues of vitamin D with low calcemic activity

In conclusion, a number vitamin D analogues have been developed that have very low calcemic activity but retain several other properties of 1,25-(OH)2D3, including the ability to differentiate leukemia and skin cells, to enhance the immune response, and to suppress parathyroid hormone levels. Althou...

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Published inKidney international. Supplement Vol. 29; pp. S22 - S27
Main Authors Brown, A J, Finch, J L, Lopez-Hilker, S, Dusso, A, Ritter, C, Pernalete, N, Slatopolsky, E
Format Journal Article
LanguageEnglish
Published United States 01.09.1990
Subjects
Animals
Antineoplastic Agents - therapeutic use
Calcitriol - analogs & derivatives
Calcitriol - chemistry
Calcitriol - therapeutic use
Humans
Hyperparathyroidism - drug therapy
Leukemia - drug therapy
Psoriasis - drug therapy
Structure-Activity Relationship
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Summary:In conclusion, a number vitamin D analogues have been developed that have very low calcemic activity but retain several other properties of 1,25-(OH)2D3, including the ability to differentiate leukemia and skin cells, to enhance the immune response, and to suppress parathyroid hormone levels. Although the mechanism of this selective activity is not yet clear, these analogues may provide new insights into the differences in action of 1,25-(OH)2D3 in various target tissues. Most importantly, the selective action of these analogues may be exploited for the treatment of diseases such as leukemia, psoriasis and hyperparathyroidism.
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ISSN:0098-6577