The antibacterial activity of a new 3-azinomethyl-rifamycin

• Published in: Il Farmaco; edizione scientifica Vol. 43; no. 7-8; p. 619
• Main Authors: Strippoli, V, Bruzzese, T, Galli, R, Simonetti, N, Tronci, N
• Format: Journal Article
• Language: English
• Published: Italy 01.07.1988
• Subjects: Animals; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Bacteria - drug effects; Enterococcus faecalis - drug effects; Mice; Microbial Sensitivity Tests; Mycobacterium tuberculosis - drug effects; Rifampin - therapeutic use; Rifamycins - chemical synthesis; Rifamycins - pharmacology; Rifamycins - therapeutic use; Staphylococcal Infections - drug therapy; Staphylococcus aureus - drug effects; Streptococcal Infections - drug therapy; Streptococcus pyogenes - drug effects
• ISSN: 0430-0920

The new 3-azinomethyl-rifamycin, SPA-S-565, was shown to exert an effective antibacterial activity in vitro comparable to that of rifampicin. In fact, the antibacterial activity of SPA-S-565 against numerous Gram-positive cocci belonging to Staphylococcus and Streptococcus species as well as against 20 strains of Mycobacterium tuberculosis, was similar to that of rifampicin. In Swiss albino mice intraperitoneally infected with Staphylococcus aureus Oxford strain or Streptococcus pyogenes, the protective activity of SPA-S-565 and rifampicin was quite remarkable, and no significant difference was noted between the two antibiotics. In M. tuberculosis-infected mice treated with the antibacterial agents every seven days, the protection exerted by SPA-S-565 was significantly greater than that exerted by rifampicin.