Drug sensitivity and environmental adaptation of mycobacterial cell wall components

The intrinsic resistance of many mycobacterial species to chemotherapy is largely attributable to their impermeable cell wall. The composition of the cell wall of a particular species appears to be influenced by the environmental niche that the species occupies. The complex regulatory and biosynthet...

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Bibliographic Details
Published inTrends in microbiology (Regular ed.) Vol. 4; no. 7; pp. 275 - 281
Main Authors Barry, 3rd, C E, Mdluli, K
Format Journal Article
LanguageEnglish
Published England 01.07.1996
Subjects
Adaptation, Physiological
Cell Wall - chemistry
Cell Wall - drug effects
Cell Wall - physiology
Ethambutol - pharmacology
Isoniazid - pharmacology
Lipid Bilayers - chemistry
Lipopolysaccharides - metabolism
Models, Biological
Mycobacterium - drug effects
Mycobacterium - physiology
Mycobacterium - ultrastructure
Permeability
Phosphatidylinositols - physiology
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Summary:The intrinsic resistance of many mycobacterial species to chemotherapy is largely attributable to their impermeable cell wall. The composition of the cell wall of a particular species appears to be influenced by the environmental niche that the species occupies. The complex regulatory and biosynthetic pathways involved in cell wall biosynthesis and construction offer useful chemotherapeutic targets against mycobacteria.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0966-842X
DOI:10.1016/0966-842X(96)10031-7