Soft tissue myofibroblastomas

Five well-circumscribed solitary soft tissue tumors composed of myofibroblasts are described and termed myofibroblastomas. By light microscopy these lesions are characterized by short, intersecting, or crisscrossing fascicles of spindle cells, sometimes associated with foci of necrosis and/or mitoti...

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Bibliographic Details
Published inModern pathology Vol. 4; no. 5; p. 571
Main Authors Herrera, G A, Johnson, W W, Lockard, V G, Walker, B L
Format Journal Article
LanguageEnglish
Published United States 01.09.1991
Subjects
Actins - analysis
Adult
Cell Transformation, Neoplastic - pathology
Cell Transformation, Neoplastic - ultrastructure
Child
Desmin - analysis
Fibroblasts - chemistry
Fibroblasts - pathology
Fibroblasts - ultrastructure
Humans
Immunohistochemistry
Infant
Infant, Newborn
Leiomyoma - chemistry
Leiomyoma - pathology
Leiomyoma - ultrastructure
Male
Microscopy, Electron
Middle Aged
Neoplasms, Muscle Tissue - chemistry
Neoplasms, Muscle Tissue - pathology
Neoplasms, Muscle Tissue - ultrastructure
Soft Tissue Neoplasms - chemistry
Soft Tissue Neoplasms - pathology
Soft Tissue Neoplasms - ultrastructure
Vimentin - analysis
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Summary:Five well-circumscribed solitary soft tissue tumors composed of myofibroblasts are described and termed myofibroblastomas. By light microscopy these lesions are characterized by short, intersecting, or crisscrossing fascicles of spindle cells, sometimes associated with foci of necrosis and/or mitotic activity with less than three mitoses per 10 high power fields. Myofibroblastomas show well-defined myofibroblastic differentiation ultrastructurally with peripheral myofilaments and vimentin, actin, and desmin immunocytochemistry positivity. The five tumors described occurred in patients of various age groups, including one congenital, and in a variety of soft tissue locations. It is important to recognize this benign soft tissue neoplasm to avoid confusion with other soft tissue tumors and to separate this lesion from other myofibromatosis. This study elucidates the spectrum of light microscopic, ultrastructural, and immunocytochemistry findings of soft tissue myofibroblastomas and establishes this soft tissue tumor as a specific clinico-pathologic entity.
ISSN:0893-3952