Serum anti-EBV IgA is inversely related to tumor infiltration by surface IgA positive lymphocytes in nasopharyngeal carcinoma

The mean number of tumor-infiltrating lymphoid cells with surface IgA was moderately higher in primary nasopharyngeal carcinoma (NPC) than in their neck gland metastases or in other head and neck tumors. Within the group of primary NPC, patients with large numbers of IgA positive infiltrating cells...

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Bibliographic Details
Published inBiomedicine & pharmacotherapy Vol. 37; no. 1; p. 41
Main Authors Gunvén, P, Klein, G, Henle, W, Henle, G, Forsby, N
Format Journal Article
LanguageEnglish
Published France 1983
Subjects
Antibodies, Viral - analysis
Herpesvirus 4, Human - immunology
Humans
Immunoglobulin A - analysis
Lymphocytes - immunology
Nasopharyngeal Neoplasms - immunology
Neoplasm Invasiveness
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Summary:The mean number of tumor-infiltrating lymphoid cells with surface IgA was moderately higher in primary nasopharyngeal carcinoma (NPC) than in their neck gland metastases or in other head and neck tumors. Within the group of primary NPC, patients with large numbers of IgA positive infiltrating cells had a significantly lower mean IgA antibody titer to Epstein-Barr viral capsid antigen. It is unlikely therefore that the unique, frequent elevation of this antibody titer in NPC is due to stimulation of infiltrating IgA positive lymphoid cells among the virus-containing epithelial tumor cells.
ISSN:0753-3322