Genetics of susceptibility to oral tolerance to ovalbumin

Inbred mouse strains vary widely in their susceptibility to the induction of tolerance following oral (intragastric) administration of ovalbumin. Marked differences were found between strains that form a congenic pair differing at the H-2 complex: C3H/HeJ (H-2k) and C3H.SW (H-2b)-which were very sus...

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Published inBrazilian journal of medical and biological research Vol. 20; no. 6; pp. 785 - 790
Main Authors Vaz, N M, Rios, M J, Lopes, L M, Gontijo, C M, Castanheira, E B, Jacquemart, F, Andrade, L A
Format Journal Article
LanguageEnglish
Published Brazil 1987
Subjects
Administration, Oral
Animals
Drug Tolerance
Enzyme-Linked Immunosorbent Assay
Female
H-2 Antigens - genetics
Intestinal Mucosa - immunology
Intestinal Mucosa - metabolism
Male
Mice
Mice, Inbred A
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Inbred DBA
Mice, Inbred NZB
Ovalbumin - administration & dosage
Ovalbumin - immunology
Ovalbumin - metabolism
Species Specificity
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Summary:Inbred mouse strains vary widely in their susceptibility to the induction of tolerance following oral (intragastric) administration of ovalbumin. Marked differences were found between strains that form a congenic pair differing at the H-2 complex: C3H/HeJ (H-2k) and C3H.SW (H-2b)-which were very susceptible and resistant to tolerance induction, respectively. In contrast, no significant differences were found between A/J (H-2a) and A.BY (H-2b) congenics, which were both susceptible, nor among C57BL/10J congenics, which were uniformly resistant to tolerance induction. We conclude that H-2-linked genes determine tolerance susceptibility in conjunction with background genes.
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ISSN:0100-879X