The efficacy and safety of a 10% carbamide peroxide bleaching gel

• Published in: Quintessence international (Berlin, Germany : 1985) Vol. 29; no. 9; p. 555
• Main Authors: Matis, B A, Cochran, M A, Eckert, G, Carlson, T J
• Format: Journal Article
• Language: English
• Published: Germany 01.09.1998
• Subjects: Adult; Analysis of Variance; Chi-Square Distribution; Colorimetry; Cuspid - chemistry; Double-Blind Method; Drug Combinations; Female; Gels - therapeutic use; Humans; Incisor - chemistry; Longitudinal Studies; Male; Middle Aged; Periodontal Index; Peroxides - therapeutic use; Tooth Bleaching - methods; Tooth Discoloration - therapy; Urea - analogs & derivatives; Urea - therapeutic use
• ISSN: 0033-6572

A 6-month, double-blind study was undertaken to assess the efficacy and safety of a 10% carbamide peroxide gel designed for at-home tooth bleaching. Sixty patients were randomized into two equal subgroups balanced by age, gender, and oral health status. Shade guide measurements, color transparency photographs, and colorimeter readings were taken and evaluated at baseline and 1, 2, 3, 6, 12, and 24 weeks. The active phase of treatment lasted 14 days. At 22 weeks postbleaching (week 24 of the study), patients receiving the active agent had a 14.1 rank order difference in the shade guide from baseline, and 66% had a clinically observable color change as determined by photographic assessment. They also had a measurable, statistically significant color change from baseline to 6 months of delta E* = 5.0. The tooth color of maxillary incisors stabilized at week 6 and maxillary canines at week 12. The mean color change lost from weeks 2 to 24 was 45% (in delta E*). Transient tissue and tooth sensitivity, noted in some patients, resolved after treatment was completed. The product tested is an effective and safe tooth-whitening agent.