Acute effects of vasodilators on left-to-right shunts in infants and children

Based on the favorable experience with vasodilator therapy in adult heart disease and the results of acute dogs experiments, we undertook the hemodynamic evaluation of hydralazine and phentolamine during diagnostic cardiac catheterization. We studied seven infants and children with left-to-right (le...

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Published inPediatric pharmacology (New York, N.Y.) Vol. 1; no. 4; p. 267
Main Authors Linday, L A, Levin, A R, Klein, A A, Reidenberg, M M, Engle, M A
Format Journal Article
LanguageEnglish
Published United States 1981
Subjects
Child
Child, Preschool
Female
Heart Rate - drug effects
Heart Septal Defects - drug therapy
Hemodynamics - drug effects
Humans
Hydralazine - pharmacology
Infant
Male
Oxygen Consumption - drug effects
Phentolamine - pharmacology
Vasodilator Agents - pharmacology
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Summary:Based on the favorable experience with vasodilator therapy in adult heart disease and the results of acute dogs experiments, we undertook the hemodynamic evaluation of hydralazine and phentolamine during diagnostic cardiac catheterization. We studied seven infants and children with left-to-right (leads to R) shunts at atrial, ventricular, or ductal levels to determine whether vasodilator therapy might be useful in the treatment of infants with congestive heart failure (CHF) due to large L leads to R shunts. Shunts, flows, and resistances were measured by the indicator dilution and Fick techniques before and after administration of the drug. At a dose sufficient to produce an effect, the shunt flow increased after each drug. There is no evidence from studies at cardiac catheterization of therapeutic efficacy for vasodilators in the treatment of CHF due to cardiac L leads to R shunts.
ISSN:0270-322X