Extrarenal production of calcitriol

Under normal circumstances extrarenal sources of calcitriol probably constitutes a microendocrine system involved in cell differentiation and local intercellular communication with no influence on systemic calcium homeostasis. Under pathological conditions such as chronic renal failure, extrarenal s...

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Published inKidney international. Supplement Vol. 29; pp. S36 - S40
Main Authors Dusso, A, Finch, J, Delmez, J, Rapp, N, Lopez-Hilker, S, Brown, A, Slatopolsky, E
Format Journal Article
LanguageEnglish
Published United States 01.09.1990
Subjects
Animals
Calcitriol - metabolism
Endothelium, Vascular - metabolism
Female
Humans
Keratinocytes - metabolism
Kidney Failure, Chronic - metabolism
Macrophages - metabolism
Pregnancy - metabolism
Sarcoidosis - metabolism
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Summary:Under normal circumstances extrarenal sources of calcitriol probably constitutes a microendocrine system involved in cell differentiation and local intercellular communication with no influence on systemic calcium homeostasis. Under pathological conditions such as chronic renal failure, extrarenal sources have the potential to normalize serum calcitriol after adequate stimulation (such as, 25(OH)D administration). Extrarenal 1,25-(OH)2D3 synthesis is controlled by physiological levels of calcitriol. However, in sarcoidosis and other granulomatous diseases, 1,25-(OH)2D3 production by macrophages is deregulated, causing severe alterations in systemic calcium homeostasis.
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ISSN:0098-6577