Acidic alpha-D-mannosidase in phenotypically different leukemic lymphoid cells

The activity of acid alpha-mannosidase in phenotypically characterized lymphoid cells, isolated from peripheral blood, spleen and lymph nodes of patients with various lymphoproliferative disorders has been studied. Cells with different immunophenotypes were shown to have different alpha-mannosidase...

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Bibliographic Details
Published inBiochemistry international Vol. 28; no. 6; p. 1079
Main Authors Ushakova, N A, Samojlova, R S, Preobrazhenskaya, M E
Format Journal Article
LanguageEnglish
Published Australia 01.12.1992
Subjects
alpha-Mannosidase
Humans
Immunophenotyping
Leukemia - blood
Leukemia - enzymology
Leukemia - immunology
Lymph Nodes - enzymology
Lymph Nodes - immunology
Lymphoid Tissue - cytology
Lymphoid Tissue - enzymology
Mannosidases - metabolism
Spleen - enzymology
Spleen - immunology
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Summary:The activity of acid alpha-mannosidase in phenotypically characterized lymphoid cells, isolated from peripheral blood, spleen and lymph nodes of patients with various lymphoproliferative disorders has been studied. Cells with different immunophenotypes were shown to have different alpha-mannosidase activity levels. The lowest alpha-mannosidase activity was observed in cells phenotypically corresponding to early B cells obtained from B-CLL patients. The highest activity was determined in cells with phenotypes of activated, CD11c-expressing B cells from B-NHL and HCL patients. There were considerable differences in alpha-mannosidase activity between peripheral blood and spleen lymphoid cells of B-NHL patients with spleen damage. The data obtained may be used in classification, primary diagnosis and staging of hematopoietic malignancies.
ISSN:0158-5231