Myosin function in the motile behaviour of cells

Cells undergo a wide variety of movements, such as directed locomotion, extension and retraction of cell surface projections, saltatory movement of intracellular particles and cytoplasmic streaming. These events involve changes in the organization and function of cytoskeletal structures that contain...

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Bibliographic Details
Published inSymposia of the Society for Experimental Biology Vol. 47; p. 375
Main Author Manstein, D J
Format Journal Article
LanguageEnglish
Published England 1993
Subjects
Actins - physiology
Animals
Cell Movement - physiology
Cytoskeleton - physiology
Dictyostelium - cytology
Models, Biological
Myosins - physiology
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Summary:Cells undergo a wide variety of movements, such as directed locomotion, extension and retraction of cell surface projections, saltatory movement of intracellular particles and cytoplasmic streaming. These events involve changes in the organization and function of cytoskeletal structures that contain actin and myosin. Dictyostelium has proven to be a very useful model system for studying these events. Its actomyosin-based motility resembles that of mammalian cells and has been extensively characterized, from the standpoints both of biochemistry and cell biology. Furthermore, the Dictyostelium cytoskeleton can be specifically altered using gene-targeting and other molecular genetic approaches.
ISSN:0081-1386