Changes in gene expression during the sleep-waking cycle: a new view of activating systems

Moruzzi pioneered the notion of ascending activating systems that were responsible for the electrophysiological activation characterizing the transition from sleep to waking. This paper proposes to extend the notion of electrophysiological activation to the domain of gene expression. Evidence is rev...

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Bibliographic Details
Published inArchives italiennes de biologie Vol. 134; no. 1; p. 21
Main Authors Tononi, G, Cirelli, C, Pompeiano, M
Format Journal Article
LanguageEnglish
Published Italy 01.12.1995
Subjects
Animals
Arousal - genetics
Arousal - physiology
Circadian Rhythm - physiology
Gene Expression Regulation - physiology
Genes, Immediate-Early
Humans
Models, Neurological
Nerve Tissue Proteins - biosynthesis
Nerve Tissue Proteins - genetics
Neuronal Plasticity - genetics
Neuronal Plasticity - physiology
Neurotransmitter Agents - physiology
Rats
RNA, Messenger - biosynthesis
RNA, Messenger - genetics
Sleep Stages - genetics
Sleep Stages - physiology
Wakefulness - genetics
Wakefulness - physiology
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Summary:Moruzzi pioneered the notion of ascending activating systems that were responsible for the electrophysiological activation characterizing the transition from sleep to waking. This paper proposes to extend the notion of electrophysiological activation to the domain of gene expression. Evidence is reviewed indicating that in the transition between sleep and waking there is, together with a change in neuronal firing patterns, a change in patterns of gene expression in widespread regions of the brain. The hypothesis is presented that changes in the activity of neuromodulatory systems with diffuse projections may subserve the diffuse, tonic and phasic activation of both neuronal responses and of gene expression. Finally, the paper discusses the possibility that such changes in gene expression may be of importance for plastic phenomena and for the functional consequences of sleep.
ISSN:0003-9829