Some changes in immunity and blood in relation to clinical states of dengue hemorrhagic fever patients in Vietnam

The role of immunological factors in the pathogenesis of Dengue Hemorrhagic Fever (DHF), particularly Dengue Shock Syndrome (DSS) was studied. The complement activity, circulating immune complex (IC), histamine level, platelets and leucocytes were determined in the blood of 30 patients and 43 health...

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Bibliographic Details
Published inHaematologia Vol. 24; no. 1; p. 13
Main Authors Phan, D T, Ha, N T, Thuc, L T, Diet, N H, Phu, L V, Ninh, L Y, An, V T
Format Journal Article
LanguageEnglish
Published Netherlands 1991
Subjects
Adolescent
Adult
Antigen-Antibody Complex - blood
Child
Child, Preschool
Complement System Proteins - metabolism
Dengue - blood
Dengue - immunology
Female
Follow-Up Studies
Histamine - blood
Humans
Leukocyte Count
Male
Platelet Count
Vietnam
Vietnam
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Summary:The role of immunological factors in the pathogenesis of Dengue Hemorrhagic Fever (DHF), particularly Dengue Shock Syndrome (DSS) was studied. The complement activity, circulating immune complex (IC), histamine level, platelets and leucocytes were determined in the blood of 30 patients and 43 healthy persons. The results showed a significant decrease in complement activity, platelet and neutrophil counts, an increase of histamine level (P less than 0.001), and the presence of circulating IC in 80 per cent of our patients. Furthermore, a marked correlation was found between the changes of the above parameters and the clinical stages of the disease. These parameters can be used in the prognostics of the pre-shock and shock syndrome of DHF.
ISSN:0017-6559