Gastric parietal cell carcinoma with an unusual, lymphoma-like histologic appearance: report of a case

We report a case of gastric carcinoma with an unusual histologic appearance and type of cellular differentiation. The tumor was resected from an 85-yr-old man who presented with epigastric pain and monoclonal gammopathy. The tumor was antral in location and transmurally infiltrated the stomach wall....

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Bibliographic Details
Published inModern pathology Vol. 2; no. 5; p. 536
Main Authors Robey-Cafferty, S S, Ro, J Y, McKee, E G
Format Journal Article
LanguageEnglish
Published United States 01.09.1989
Subjects
Aged
Aged, 80 and over
Carcinoma - metabolism
Carcinoma - ultrastructure
Diagnosis, Differential
Follow-Up Studies
Humans
Keratins - metabolism
Lymphoma - ultrastructure
Male
Parietal Cells, Gastric - metabolism
Parietal Cells, Gastric - ultrastructure
Stomach Neoplasms - metabolism
Stomach Neoplasms - ultrastructure
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Summary:We report a case of gastric carcinoma with an unusual histologic appearance and type of cellular differentiation. The tumor was resected from an 85-yr-old man who presented with epigastric pain and monoclonal gammopathy. The tumor was antral in location and transmurally infiltrated the stomach wall. Histologically, the tumor closely resembled a lymphoma with diffuse poorly cohesive sheets of tumor cells interspersed with histiocytes. Immunohistochemical study, however, clearly demonstrated the epithelial nature of this tumor. Electron microscopy also revealed evidence of epithelial differentiation and features of parietal cell differentiation. In this report, we describe the light and electron microscopic findings, immunohistochemical staining properties, and DNA flow cytometric findings of this tumor and briefly review the literature on parietal cell carcinomas.
ISSN:0893-3952