Neutrophil and monocyte chemotaxis in acutely infected patients with cystic fibrosis

The purpose of this investigation was to determine if an acquired dysfunction of neutrophil or monocyte chemotaxis contributes to the susceptibility of cystic fibrosis patients to persistent infection. Leukocyte chemotaxis and the ability to generate chemotactic factors were measured in acutely infe...

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Bibliographic Details
Published inAnnals of allergy Vol. 45; no. 4; p. 217
Main Authors Church, J A, Keens, T G, Wang, C I
Format Journal Article
LanguageEnglish
Published United States 01.10.1980
Subjects
Acute Disease
Adolescent
Bacterial Infections - complications
Chemotactic Factors - biosynthesis
Chemotaxis, Leukocyte
Cystic Fibrosis - complications
Humans
Monocytes
Neutrophils
Zymosan - pharmacology
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Summary:The purpose of this investigation was to determine if an acquired dysfunction of neutrophil or monocyte chemotaxis contributes to the susceptibility of cystic fibrosis patients to persistent infection. Leukocyte chemotaxis and the ability to generate chemotactic factors were measured in acutely infected cystic fibrosis patients and clinically well adult volunteers with an agarose technique. Chemotaxis of neutrophils and monocytes from cystic fibrosis patients were not found to differ from those of normal adult cells. Sera from test subjects produce chemotactic factors for normal neutrophils and monocytes.
ISSN:0003-4738