Pulmonary dysfunction in systemic lupus erythematosus:prevalence classification and correlation with other organ involvement

Forty-three patients known to have systemic lupus erythematosus (SLE) underwent pulmonary function evaluation. Pulmonary dysfunction was noted in 38 patients (88%). The most common abnormality was an impairment in diffusing capacity, present in 31 patients (72%), while reduction in lung volumes was...

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Bibliographic Details
Published inJournal of rheumatology Vol. 7; no. 2; p. 187
Main Authors Silberstein, S L, Barland, P, Grayzel, A I, Koerner, S K
Format Journal Article
LanguageEnglish
Published Canada 01.03.1980
Subjects
Adolescent
Adult
Azathioprine - therapeutic use
DNA - immunology
Expiratory Reserve Volume
Female
Humans
Lung - diagnostic imaging
Lung - physiopathology
Lung Volume Measurements
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - drug therapy
Lupus Erythematosus, Systemic - pathology
Lupus Erythematosus, Systemic - physiopathology
Male
Middle Aged
Prednisone - therapeutic use
Radiography
Smoking
Thioguanine - therapeutic use
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Summary:Forty-three patients known to have systemic lupus erythematosus (SLE) underwent pulmonary function evaluation. Pulmonary dysfunction was noted in 38 patients (88%). The most common abnormality was an impairment in diffusing capacity, present in 31 patients (72%), while reduction in lung volumes was present in 21 patients (49%), hypoxia in 19 patients (44%), and airways obstruction in 4 patients (9%). When compared to pulmonary symptoms and signs and chest roentgenogram, the pulmonary function tests were the most sensitive means of uncovering pulmonary involvement in SLE. No correlation was found in either the classification or severity of the pulmonary function abnormality when compared with other measures of lupus activity, such as serology, immune complexes in skin biopsy, and renal biopsy.
ISSN:0315-162X