Release and retention of labelled DNA in the thymus and spleen of irradiated mice

The process of release and retention of labelled DNA in thymus and spleen of normal and irradiated (60Co) mice has been studied after administration of 3H-thymidine. The results indicate that the dividing fraction of lymphoid cells is more resistant to radiation than the fraction of nondividing lymp...

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Bibliographic Details
Published inStrahlentherapie Vol. 151; no. 2; p. 156
Main Authors Suciu, D, Uray, Z, Abraham, A D
Format Journal Article
LanguageEnglish
Published Germany 01.02.1976
Subjects
Animals
Cell Division - radiation effects
Cobalt Radioisotopes
DNA - metabolism
Lymphocytes - radiation effects
Male
Mice
Mitosis - radiation effects
Radiation Effects
Spleen - metabolism
Spleen - radiation effects
T-Lymphocytes - radiation effects
Thymidine - metabolism
Thymus Gland - cytology
Thymus Gland - metabolism
Thymus Gland - radiation effects
Time Factors
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Summary:The process of release and retention of labelled DNA in thymus and spleen of normal and irradiated (60Co) mice has been studied after administration of 3H-thymidine. The results indicate that the dividing fraction of lymphoid cells is more resistant to radiation than the fraction of nondividing lymphocytes. The time courses of the specific activities of DNA in thymus and spleen were different especially after irradiation with lethal doses. It is suggested that the process of depletion in the lymphoid series is probably similar for both thymus and spleen but, the different cellular composition of these organs led to apparently unrelated results.
ISSN:0039-2073