Hypermagnesemia following aluminum phosphide poisoning

Aluminum phosphide (ALP) is highly toxic to the lungs, heart and blood vessels causing pulmonary edema, shock and arrhythmias. There is massive focal myocardial damage resulting in raised cardiac enzymes. This study included 92 patients of proven ALP poisoning. The age varied between 20-50 years and...

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Published inInternational journal of clinical pharmacology, therapy, and toxicology Vol. 29; no. 2; p. 82
Main Authors Singh, R B, Singh, R G, Singh, U
Format Journal Article
LanguageEnglish
Published Germany 01.02.1991
Subjects
Adolescent
Adult
Aluminum Compounds
Electrocardiography - drug effects
Female
Humans
Magnesium - blood
Male
Middle Aged
Phosphines - poisoning
Sodium - blood
Suicide, Attempted
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Summary:Aluminum phosphide (ALP) is highly toxic to the lungs, heart and blood vessels causing pulmonary edema, shock and arrhythmias. There is massive focal myocardial damage resulting in raised cardiac enzymes. This study included 92 patients of proven ALP poisoning. The age varied between 20-50 years and the majority (74) were females. Clinical manifestations were nausea and vomiting (92), dyspnea and palpitation (72 each), cyanosis (54), hypotension (32) and shock (46) etc. Cardiac arrhythmias were present in 80 cases and hypermagnesemia in 78 patients. Mean serum magnesium level (1.95 +/- 0.18 mE/l) was significantly (p less than 0.01) raised compared to mean magnesium level in control subjects (1.62 +/- 0.26 mEq/l). Hypermagnesemia results from myocardial and liver damage and to our knowledge has not been described in the literature. Of 92 cases studied, 66 died, 60 of whom died within 24 hours of ALP ingestion. Treatment is supportive.
ISSN:0174-4879