Identification of a methylated catechol metabolite of glutethimide (Doriden) in human urine

A new metabolite of glutethimide has been isolated and identified as a methylated catechol. Gas chromatographic parameters as well as mass spectral data are presented which clearly reveal this metabolite to be present in enzymatically hydrolyzed urine of patients severely intoxicated by the parent d...

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Bibliographic Details
Published inResearch communications in chemical pathology and pharmacology Vol. 13; no. 2; p. 193
Main Authors Andresen, B D, Templeton, J L, Hammer, R H, Panzik, H L, Moldowan, M J
Format Journal Article
LanguageEnglish
Published United States 01.02.1976
Subjects
Catechols - metabolism
Chemical Phenomena
Chemistry
Glutethimide - analogs & derivatives
Glutethimide - urine
Humans
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Summary:A new metabolite of glutethimide has been isolated and identified as a methylated catechol. Gas chromatographic parameters as well as mass spectral data are presented which clearly reveal this metabolite to be present in enzymatically hydrolyzed urine of patients severely intoxicated by the parent drug.
ISSN:0034-5164