Potentials and limitations of a clonogenic cell assay for human brain tumors

Single cells from biopsies of ten malignant gliomas were treated with 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) in vitro, and tumor cell survival was compared to patient response to nitrosourea therapy. The limitations of the methods and their interpretations and future prospects for clonogenic c...

Full description

Saved in:
Bibliographic Details
Published inCancer treatment reports Vol. 65 Suppl 2; p. 61
Main Authors Rosenblum, M L, Dougherty, D V, Deen, D F, Wilson, C B
Format Journal Article
LanguageEnglish
Published United States 1981
Subjects
Adult
Aged
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - drug therapy
Carmustine - therapeutic use
Cells, Cultured
Clone Cells
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical - methods
Female
Glioma - diagnostic imaging
Glioma - drug therapy
Humans
Male
Middle Aged
Tomography, X-Ray Computed
Online AccessGet more information

Cover

More Information
Summary:Single cells from biopsies of ten malignant gliomas were treated with 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) in vitro, and tumor cell survival was compared to patient response to nitrosourea therapy. The limitations of the methods and their interpretations and future prospects for clonogenic cell analyses are discussed.
ISSN:0361-5960