Central anticholinergic actions of doxepin in rabbits

Neuropharmacological effects of doxepin were studied in rabbits to reveal fundamental actions which might explain its clinical efficacy. The results indicate that central effects of this compound are similar to those reported for atropine and the tricyclic antidepressants. In this regard, doxepin pr...

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Bibliographic Details
Published inArchives internationales de pharmacodynamie et de thérapie Vol. 213; no. 1; p. 113
Main Authors Moore, R H, White, R P
Format Journal Article
LanguageEnglish
Published Belgium 01.01.1975
Subjects
Animals
Behavior, Animal - drug effects
Blood Pressure - drug effects
Doxepin - pharmacology
Electroencephalography
Female
Heart Rate - drug effects
Male
Methamphetamine - pharmacology
Parasympatholytics - pharmacology
Physostigmine - pharmacology
Rabbits
Respiration - drug effects
Time Factors
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Summary:Neuropharmacological effects of doxepin were studied in rabbits to reveal fundamental actions which might explain its clinical efficacy. The results indicate that central effects of this compound are similar to those reported for atropine and the tricyclic antidepressants. In this regard, doxepin produced mydriasis and EEG synchrony without producing overt signs of sleep. It inhibited in a dose-related manner the EEG activation produced by physostigmine. It inhibited the EEG, but not behavioral, effects of methamphetamine. Doxepin enhanced some of the behavioral effects of methamphetamine, as does atropine.
ISSN:0003-9780