Etiology and prognosis of cryptogenic liver cirrhosis: possible contribution of hepatitis B virus

Three female patients without type B or type C viral hepatitis, alcoholic, metabolic or autoimmune liver disease, were selected from 250 cases with histologically proven liver cirrhosis (M:F = 183:67). All three cases showed at least one positive aspect among three parameters of serum anti-HBc (RPHA...

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Bibliographic Details
Published inJournal of medicine Vol. 28; no. 1-2; p. 31
Main Authors Watanabe, A, Aiba, N, Harada, R, Miyabayashi, C, Entani, A, Wakabayashi, H, Nishimori, H, Kuwabara, Y
Format Journal Article
LanguageEnglish
Published United States 1997
Subjects
Aged
Base Sequence
Carcinoma, Hepatocellular - etiology
DNA Primers - genetics
DNA, Viral - blood
DNA, Viral - genetics
Female
Hepatitis B - complications
Hepatitis B - virology
Hepatitis B virus - genetics
Hepatitis B virus - isolation & purification
Hepatitis B virus - pathogenicity
Hepatitis C - complications
Humans
Liver Cirrhosis - etiology
Liver Neoplasms - etiology
Male
Middle Aged
Mutation
Polymerase Chain Reaction
Prognosis
Time Factors
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Summary:Three female patients without type B or type C viral hepatitis, alcoholic, metabolic or autoimmune liver disease, were selected from 250 cases with histologically proven liver cirrhosis (M:F = 183:67). All three cases showed at least one positive aspect among three parameters of serum anti-HBc (RPHA, x1), HBV-DNA (gene S, nested PCR) and liver HBs and/or pre-S2 antigen (immunoperoxidase methods). Two cases may suggest a spontaneous disappearance of HBV from sera. Another case may suggest a contribution of mutant HBV which can not be detected by the routine tests. These HBV-related cirrhotic patients have done well clinically and have not been associated with hepatocellular carcinoma during the period from 6 to 12 years of follow-up when compared with 59.6% and 65.4% prevalence of hepatocarcinogenesis in type B and type C hepatitis-associated cirrhosis during the observation period of six and seven years on average, respectively.
ISSN:0025-7850