5-Hydroxytryptophan versus methysergide in the prophylaxis of migraine. Randomized clinical trial

One hundred and twenty-four migraineurs were treated randomly with 5-hydroxytryptophan (5-HTP) or with methysergide (M). The two groups were homogeneous without significant statistical differences with respect to age, sex, pill use, type of migraine and frequency of attacks before entry. A significa...

Full description

Saved in:
Bibliographic Details
Published inEuropean neurology Vol. 25; no. 5; p. 327
Main Authors Titus, F, Dávalos, A, Alom, J, Codina, A
Format Journal Article
LanguageEnglish
Published Switzerland 1986
Subjects
5-Hydroxytryptophan - therapeutic use
Adolescent
Adult
Child
Clinical Trials as Topic
Female
Humans
Male
Methysergide - therapeutic use
Middle Aged
Migraine Disorders - prevention & control
Random Allocation
Online AccessGet more information

Cover

More Information
Summary:One hundred and twenty-four migraineurs were treated randomly with 5-hydroxytryptophan (5-HTP) or with methysergide (M). The two groups were homogeneous without significant statistical differences with respect to age, sex, pill use, type of migraine and frequency of attacks before entry. A significant improvement was observed in 75% of the patients treated with M and in 71% of the cases treated with 5-HTP. The most beneficial effect of 5-HTP appears to be felt with regard to the intensity and duration rather than the frequency of the attacks. Side effects were more frequent in the M group than in the 5-HTP group. These results suggest that 5-HTP could be a treatment of choice in the prophylaxis of migraine.
ISSN:0014-3022
DOI:10.1159/000116030