Morphometric study of malformations induced by hypervitaminosis A on rat fetus Meckel cartilage, maxillary bone and mandible

Morphological and histological studies were carried out to determine the effects on fetal development in rats of a single intraperitoneal injection of 150,000 I.U. of vitamin A, given to the mothers on the 10th day of gestation. The Meckel cartilage of malformed animals appeared to be diminished, wi...

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Bibliographic Details
Published inAnatomischer Anzeiger Vol. 152; no. 4; p. 329
Main Authors Lopes, R A, Souza, M L, Azoubel, R
Format Journal Article
LanguageEnglish
Published Germany 1982
Subjects
Abnormalities, Drug-Induced - pathology
Animals
Cartilage - pathology
Female
Fetus - pathology
Histological Techniques
Male
Mandible - pathology
Maxilla - pathology
Rats
Rats, Inbred Strains
Skull - drug effects
Vitamin A - adverse effects
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Summary:Morphological and histological studies were carried out to determine the effects on fetal development in rats of a single intraperitoneal injection of 150,000 I.U. of vitamin A, given to the mothers on the 10th day of gestation. The Meckel cartilage of malformed animals appeared to be diminished, with larger nuclei, less numerous isogenous nests, smaller cellular and thin perichondrium and more abundant cartilaginous matrix, which was less deeply stained by alcian blue. The maxillary bone and mandible of the treated fetuses showed thin and poorly calcified trabeculae, smaller medullary spaces and a less fibrous, and more cellular periosteum. These data were confirmed with morphometric techniques.
ISSN:0003-2786